Although naturally occurring proteins form stable defined tertiary structures, it is well known that many proteins with non-natural sequences have unstructured conformations 1,2. This suggests that ...
The ability to design and build nonnative DNA sequences conferring specific and useful engineered functions on cells defines the field of synthetic biology. Here, we describe a synthetic biology ...
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, and Department of Biochemistry and Molecular Biology, State University of New ...
∥ Centre for High Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1 ⊥ Department of Biochemistry and Molecular Biology, University of British Columbia, ...
Multiple types of natural collagens specifically assemble and co-exist in the extracellular matrix. Although noncollagenous trimerization domains facilitate the folding of triple-helical regions, it ...
Circular permutations usually retain the native structure and function of a protein while inevitably perturbing its folding dynamics. By using simulations with a structure-based model and a rigorous ...
Circular arrangement is one of the interesting topics of Permutations. Before understanding circular arrangement let us review some important concepts of linear permutation. In linear arrangement n ...
Abstract: We consider the problem of sorting a circular permutation by super short reversals (i.e., reversals of length at most 2), a problem that finds application in comparative genomics. Polynomial ...
Imagining that protein stability needs to be kept within some limits for biological function is easy. However, is there any corresponding pressure on protein folding and, hence, the dynamic ...
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