Abstract: Objective: Simple randomization, stratified block randomization and minimization are three most commonly used allocation methods in clinical trials. Our objective was to make a comparison of ...

An essential part of any clinical trial design consists of random assignment of subjects to different treatment groups. This facilitates comparison of these groups and justifies the use of appropriate ...

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Preservation of treatment allocation randomness, achievement of treatment group size balance, and balance on prognostic baseline covariates are desirable properties of optimal randomization schemes.